PHARMACOKINETICS
Absorption: well absorbed from the gut and reaches highest blood plasma concentrations after about 3 hours.
Protein binding: 83 to 87%
Half life: 27 hours
Metabolism: extensively metabolized to 3-hydroxydesloratadine, an active metabolite, which is subsequently glucuronidated.
Excretion: approximately 87% of a 14C-desloratadine dose was equally recovered in urine and feces.

PHARMACODYNAMIC
Deslo-ODT blocks H1 receptor (GI tract, uterus, large blood vessels, and bronchial smooth muscle) and blocks the action of endogenous histamine
Leads to temporary relief of the negative symptoms (e.g. nasal congestion, watery eyes) brought on by histamine.

Seasonal & perennial allergic rhinitis
Chronic idiopathic Urticaria (hives)
Allergic dermatitis
Ocular Allergy and
Adjunct therapy in asthma and Acne

DOSAGES
The recommended dose of Deslo ODT is 5mg po qDay.

Sore throat
Nausea
Tiredness
Stomach upset
Muscle pain
Fever
Loss of appetite
Diarrhoea
Trouble sleeping

Narrow angle glaucoma
Slow metabolizers
Prostatic hypertrophy
Stenosing peptic ulcer
Pyloroduodenal obstruction
Bladder neck obstruction
Hepatic/ renal impairment