PHARMACOKINETICS
Absorption: rapidly and completely absorbed from the gastrointestinal tract and circulates mainly as unchanged drug following oral administration.
Volume of distribution: 25 L
Protein binding: >99%
Metabolism: metabolized in human hepatocytes and human microsomes to form [2-(2', 6’-dichloro-4'-hydroxy- phenylamino) phenyl]acetoxyacetic acid as the major metabolite, which is then further conjugated.
Route of elimination: via the urine where the elimination accounts for 70-80% of clearance of the drug
Half life: 4 hours
Clearance: 5 L/h

PHARMACODYNAMIC
Aceclofenac inhibits cyclooxygenase (COX) activity (esp. Cox-2). It down regulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway and contributes to reduction in pain and inflammation.

Osteoarthritis
Rheumatoid Arthritis
Ankylosing Spondylitis
Dental Pain
Traumatic Injury
ENT Pain
Post-Surgical Pain
Primary dysmenorrhea

DOSAGES
The recommended dosage of Dolace SR 200 for adult is 200mg one in the morning and other in the evening.

Abdominal pain
Constipation
Diarrhoea
Nausea
Vomiting
Skin rash
Increased liver enzymes

In patients with history of Crohn’s disease, bruising, heart, liver or kidney disease, gastrointestinal disease, blood clotting problems, systemic lupus erythematosus, elderly, during pregnancy, alcohol dependent patients & breastfeeding.