Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It has higher affinity towards COX 2 than comparison to Diclofenac.
Absorption: rapidly and completely absorbed from the gastrointestinal tract and circulates mainly as unchanged drug following oral administration.
Volume of distribution: 25 L
Protein binding: >99%
Metabolism: metabolized in human hepatocytes and human microsomes to form [2-(2', 6’-dichloro-4'-hydroxy- phenylamino) phenyl]acetoxyacetic acid as the major metabolite, which is then further conjugated.
Route of elimination: via the urine where the elimination accounts for 70-80% of clearance of the drug
Half life: 4 hours
Clearance: 5 L/h
Aceclofenac inhibits cyclooxygenase (COX) activity (esp. Cox-2). It down regulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway and contributes to reduction in pain and inflammation.
The recommended dosage of Dolace SR 200 for adult is 200mg one in the morning and other in the evening.
Increased liver enzymes
In patients with history of Crohn’s disease, bruising, heart, liver or kidney disease, gastrointestinal disease, blood clotting problems, systemic lupus erythematosus, elderly, during pregnancy, alcohol dependent patients & breastfeeding.