Valacyclovir is an antiviral drug that has been used to manage and treat various herpes infections. It is a member of the purine (guanine) nucleoside analogue drug class.
Absorption: after oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal (GI) tract and converted to acyclovir and L-valine.
Distribution: The binding of valacyclovir to human plasma proteins ranged from 13.5% to 17.9%.
Bioavailability: 54.5% ± 9.1%
Metabolism: It is metabolized by liver; valacyclovir is rapidly and nearly completely converted to acyclovir and L-valine via first pass effect.
Half life: 2.5 to 3.3 hours
After oral administration Valacyclovir metabolizes to acyclovir and valin. Acyclovir is converted to Acyclovir triphosphate which inhibits Viral DNA polymerase and then incorporates into, terminates growth and finally inactivates the virus
Shingles (Herpes zoster): The recommended dose is 1 g PO q8hr for 7 days.
Chicken pox (Varicella zoster): the recommended dose is 1g po q8hr for 7 days.
Genital herpes(Herpes simplex virus): The recommended dose is 1 g PO q12hr for 10 days
Cold sores (Herpes labialis): The recommended dose is 2 g PO q12hr for 1 day.
Elevated aspartate transaminase (AST)
Elevated alanine transaminase (ALT)
Runny or stuffy nose
Low platelet count (thrombocytopenia)
Low white blood cell count (leukopenia, neutropenia)
It should not be given in patients with suspected Hydration status
Patients with renal impairment and in elderly patients