PHARMACOKINETICS
Absorption: The absolute oral bioavailability of Itraconazole is 55%, and is maximal when taken with a full meal.
Volume of distribution: 796 ± 185 L
Protein binding: 99.8%
Metabolism: extensively metabolized by the liver into a large number of metabolites, including hydroxyitraconazole, the major metabolite.
Half life: 21 hours

PHARMACODYNAMIC
Itraconazole inhibits fungal cytochrome P-450 Lanosterol 14 α-demethylase. This enzyme converts lanosterol to ergosterol (required in fungal cell wall synthesis). Disruption of its production can alter fluidity and integrity of the cell membrane and cell wall as fungi cannot survive without Ergosterol.

Tinea pedis: 100mg/day for 30days
Tinea cruris & tinea corporis: 100mg/day for 15days.
Fungal keratitis: 100mg daily for 7-14days

Tinea pedis: 200mg daily for 7 days.
Tinea versicolor: 200mg/day for 7 days.
Toe nails: 200mg/day for 12 weeks.
Finger nails: 200mg/day for 6weeks.
Vaginal candidiasis: 200mg/day for 3 consecutive days / 200mg bid for 1 day.
Fungal keratitis: 200mg OD for 21 days

Headache
Dizziness
Rash
Nausea
Vomiting
Upset stomach
Constipation
Fever
Muscle/joint pain
Unusual or unpleasant taste
Hair loss
Impotence

Hepatotoxicity
Neuropathy
Immunocompromised patients
Cystic fibrosis
Cardiac dysrhythmias
Cardiac disease
Hearing loss